Iran and the United States are scheduled to commence a fifth round of indirect nuclear negotiations in Rome this Friday, as confirmed by Omani mediators. Despite Iran's firm stance on continuing uranium enrichment, which it deems non-negotiable, the U.S. maintains that a complete halt to enrichment is essential. The talks aim to address these critical differences and explore potential pathways to revive the 2015 nuclear agreement, which the U.S. exited in 2018. The negotiations occur against a backdrop of heightened regional tensions and skepticism about the potential for a breakthrough.