US Secretary of State Marco Rubio is anticipated to engage in a 'frank' discussion during his visit to the Vatican this week, as per US Ambassador Brian Burch.

This interaction comes following President Donald Trump's recent critical comments towards Pope Leo regarding his stance on the US-Iran war.

Burch noted that the purpose of Rubio's meeting with the Pope is to foster open dialogue and address any disagreements between the two entities in a respectful manner.

He stated, "Nations have disagreements, and I think one of the ways that you work through those is ...

through fraternity and authentic dialogue".

Burch further emphasized that Rubio's approach is centered on engaging in genuine conversations about US policy.

Trump has repeatedly criticized Pope Leo for his opposition to the US war in Iran.

In a recent interview with right-wing radio talk show host Hugh Hewitt, Trump expressed disapproval of the Pope's stance, suggesting that he endangers both Catholics and others by opposing the war on Iran.

However, it is essential to note that Pope Leo has never advocated for Iran to possess nuclear weapons but rather opposed the conflict.

Rubio, a Catholic himself, previously met Pope Leo with Vice President JD Vance after attending his inaugural mass.

This upcoming meeting is expected to focus on enhancing mutual understanding and addressing any existing differences between the US and the Vatican.

Additionally, Rubio is scheduled to meet with Italian Prime Minister Giorgia Meloni, who has defended Pope Leo's position.

Her defense minister expressed concerns that the war in Iran poses a risk to US leadership.

Pope Leo, marking his first year as leader of the Catholic Church this Friday, has recently emerged as a vocal critic of the US-Israeli war on Iran and the Trump administration's immigration policies.

The Pope has also called for dialogue between the US and Cuba to prevent violence.