Saudi Press

Saudi Arabia and the world
Saturday, Jun 21, 2025

Japanese researchers create a 'vaccine' against getting old

Japanese researchers create a 'vaccine' against getting old

Researchers at a Tokyo university say their vaccine slowed the ageing process in mice, and could even aid the treatment of ageing-related diseases.

What if you could live forever? It's a question long pondered by fictional supervillains and Silicon Valley billionaires alike.

Now researchers in Japan say they may have taken a step toward boosting human longevity with successful trials of a vaccine against the cells that contribute to the ageing process.

In laboratory trials, a drug targeting a protein contained in senescent cells - those which have naturally stopped reproducing themselves - slowed the progression of frailty in older mice, the researchers from Tokyo's Juntendo University said.

The vaccine also successfully targeted the senescent cells in fatty tissue and blood vessels, suggesting it could have a positive impact on other medical conditions linked to ageing.

"We can expect that (the vaccine) will be applied to the treatment of arterial stiffening, diabetes and other ageing-related diseases," Juntendo professor Toru Minamino told Japan's Jiji news agency.

What is cellular senescence?


Cells become senescent when they stop duplicating themselves, often in response to naturally-occurring damage to their DNA. Cellular senescence is thought to contribute to the ageing process itself, as well as ageing-related diseases like Alzheimer's and some cancers.

"Senescent cells secrete a series of factors that disrupt the function of the tissue," Dr Salvador Macip, head of the University of Leicester's Mechanisms of Cancer and Ageing Lab, told Euronews Next.

"They 'call' cells from the immune system, in theory to be cleared by them (but that eventually fails) and create a chronic low level inflammation, mixed with fibrosis," Macip said.

Macip was part of an international team of academics from universities in the UK, Spain, Nigeria and Saudi Arabia that published research on another method of tackling senescent cells in October this year.

"The biological process of ageing is very complex, therefore it is unlikely that one single strategy will completely stop it or reverse it. However, there are probably many ways to slow it down, and clearing senescent cells seems to be one of the easiest and potentially more effective," he said.

The limit on lifespan


In laboratory tests, preventing the build-up of senescent cells extended the lifespan of mice by 15 per cent, Macip told Euronews Next. Other, similar experiments have achieved as much as a 35 per cent increase, he said.

File photo. Similar experiments have reported up to a 35 per cent increase in the longevity of mice, Macip said


But before you get too excited, it's worth bearing in mind that researchers still don't know how much a living creature's lifespan can be extended.

"This is a very interesting question, and one that we still have not agreed upon. Some believe there is a 'hard' limit for human lifespan (around 130 years is the current estimate), while others think that, on paper, immortality should be feasible," Macip said.

"It's still early to know how much life can be extended and whether there's a limit or not".

We may not have to wait too long for an answer, though.

"The field of anti-ageing research is advancing very fast. In the last decade, there have been many key discoveries," Macip said.

"The person that will take the first anti-ageing pill has probably already been born".

Newsletter

Related Articles

Saudi Press
0:00
0:00
Close
Israel Confirms Assassination of Quds Force Commander in Tehran
16 Billion Login Credentials Leaked in Unprecedented Cybersecurity Breach
Senate hearing on who was 'really running' Biden White House kicks off
G7 Leaders Fail to Reach Consensus on Key Global Issues
Mass exodus in Tehran as millions try to flee following Trump’s evacuation order
Iranian Military Officers Reportedly Seek Contact with Reza Pahlavi, Signal Intent to Defect
Vietnam Emerges as Luxury Yacht Destination for Ultra‑Rich
China's Iranian Oil Imports Face Disruption Amid Escalating Middle East Tensions
Trump Demands Iran's Unconditional Surrender Amid Escalating Conflict
Israeli Airstrike Targets Iranian State TV in Central Tehran
President Trump is leaving the G7 summit early and has ordered the National Security Council to the Situation Room
Netanyahu Signals Potential Regime Change in Iran
Analysts Warn Iran May Resort to Unconventional Warfare
Iranian Regime Faces Existential Threat Amid Conflict
Energy Infrastructure Becomes War Zone in Middle East
Iran Conducts Ballistic Missile Launches Amid Heightened Tensions with Israel
Iran Signals Openness to Nuclear Negotiations Amid Ongoing Regional Tensions
Shock Within Iran’s Leadership: Khamenei’s Failed Plan to Launch 1,000 Missiles Against Israel
Trump's Anti-War Stance Tested Amid Israel-Iran Conflict
UK Deploys Jets to Middle East Amid Rising Tensions
Exiled Iranian Prince Reza Pahlavi Urges Overthrow of Khamenei Regime
Wreck of $17 Billion San José Galleon Identified Off Colombia After 300 Years
Iran Launches Extensive Missile Attack on Israel Following Israeli Strikes on Nuclear Sites
Israel Issues Ultimatum to Iran Over Potential Retaliation and Nuclear Facilities
Black Box Recovered from Air India Crash Site
Coinbase CEO Warns Bitcoin Could Supplant US Dollar Amid Mounting National Debt
Trump to Iran: Make a Deal — Sign or Die
Operation "Like a Lion": Israel Strikes Iran in Unprecedented Offensive
Israel Launches 'Operation Rising Lion' Targeting Iranian Nuclear and Military Sites
Israeli Forces Intercept Gaza-Bound Aid Vessel Carrying Greta Thunberg
IMF Warns of Severe Global Trade War Impacts on Emerging Markets
Syria to Reconnect to Global Economy After 14 Years of Isolation
Israel Confirms Arming Gaza Clan to Counter Hamas Influence
Global News Roundup: From Ukraine's strategic military strikes and Russia's demands and Tensions Escalate in Ukraine, to serious legal issues faced by Britons in Bali and Trump's media criticism, the latest developments highlight a turbulent landscape
U.S. Reduces Military Presence in Syria
Trump Demands Iran End All Uranium Enrichment in Nuclear Talks
Iran Warns Europe Against Politicizing UN Nuclear Report
Paris Saint-Germain's Greatest Triumph Is Football’s Lowest Point
OPEC+ Agrees to Increase Oil Output for Third Consecutive Month
Turkey Detains Istanbul Officials Amid Anti-Corruption Crackdown
Meta and Anduril Collaborate on AI-Driven Military Augmented Reality Systems
EU Central Bank Pushes to Replace US Dollar with Euro as World’s Main Currency
European and Arab Ministers Convene in Madrid to Address Gaza Conflict
U.S. Health Secretary Ends Select COVID-19 Vaccine Recommendations
Trump Warns Putin Is 'Playing with Fire' Amid Escalating Ukraine Conflict
India and Pakistan Engage Trump-Linked Lobbyists to Influence U.S. Policy
U.S. Halts New Student Visa Interviews Amid Enhanced Security Measures
Trump Administration Cancels $100 Million in Federal Contracts with Harvard
SpaceX Starship Test Flight Ends in Failure, Mars Mission Timeline Uncertain
King Charles Affirms Canadian Sovereignty Amid U.S. Statehood Pressure
×