Pope Francis appealed for an end to the spiral of violence in the Middle East following Iran's missile and drone attack on Israel.
He expressed concern and pain over the worsening situation and prayed against the risk of a greater conflict.
Pope Francis called for peace between Israelis and Palestinians, urging all countries to support the creation of two states for them to live in security.
He repeated his calls for a ceasefire in Gaza and negotiations, while demanding help for the humanitarian crisis in Gaza and the immediate release of hostages held by Hamas.
The Pope's statements came amidst the latest wave of violence in the region.