Saudi Press

Saudi Arabia and the world
Saturday, Jun 21, 2025

Vaccine Mix-And-Match Approach Bolsters Antibodies, Says Study

Vaccine Mix-And-Match Approach Bolsters Antibodies, Says Study

The US government-sponsored trial is the first major US study to compare the effects of using different vaccines as boosters from the initial shot or shots.
Mixing Covid vaccines produces as much or more antibodies as using the same shot as a booster, according to preliminary results of a widely awaited US government-sponsored trial.

The trial is the first major US study to compare the effects of using different vaccines as boosters from the initial shot or shots. The complicated, 9-arm trial involved over 450 people and measured the effects from giving a booster shot of the Moderna Inc, Pfizer Inc.-BioNTech SE or Johnson & Johnson vaccines to those who had originally gotten a different vaccine.

Overall, the results found that mixing-and-matching resulted in comparable or higher levels of neutralizing antibodies compared to same-vaccine boosting, the researchers said in the preprint posted on medRxiv.org. Rates of adverse events were similar across all the different booster groups, the study found.

"These data suggest that if a vaccine is approved or authorized as a booster, an immune response will be generated regardless of the primary Covid-19 vaccination regimen," the researchers said in their conclusion.

The results from the ongoing trial have not yet been peer reviewed and published in a medical journal. More detail about the study is expected to be disclosed Friday afternoon at a meeting of FDA advisory panel, where researchers conducting the trial are scheduled to give a presentation on their early findings.

Mixing and matching boosters has become an increasingly important issue. Many countries outside the US have used the method for in an attempt to maximize vaccine effectiveness or avoid rare side effects that have been associated with some shots.

In the US, some people who received the Johnson & Johnson shot may be interested in getting a messenger RNA shot as a booster. Also, mixing-and-matching could make it easier for officials to roll out boosters more broadly, as people getting boosters could receive any Covid vaccine on hand at their pharmacy and wouldn't have to seek out the specific shot they had gotten previously.

Outside the US, concerns about rare blood clots associated with AstraZeneca Plc's vaccine led to many countries in Europe to pause use of the shot and instead administer a different second dose. In the UK health authorities have rolled out a booster program for an extra dose of the Pfizer vaccine as the preferred option, and also offered a half dose of the Moderna shot as an alternative.
Newsletter

Related Articles

Saudi Press
0:00
0:00
Close
Israel Confirms Assassination of Quds Force Commander in Tehran
16 Billion Login Credentials Leaked in Unprecedented Cybersecurity Breach
Senate hearing on who was 'really running' Biden White House kicks off
G7 Leaders Fail to Reach Consensus on Key Global Issues
Mass exodus in Tehran as millions try to flee following Trump’s evacuation order
Iranian Military Officers Reportedly Seek Contact with Reza Pahlavi, Signal Intent to Defect
Vietnam Emerges as Luxury Yacht Destination for Ultra‑Rich
China's Iranian Oil Imports Face Disruption Amid Escalating Middle East Tensions
Trump Demands Iran's Unconditional Surrender Amid Escalating Conflict
Israeli Airstrike Targets Iranian State TV in Central Tehran
President Trump is leaving the G7 summit early and has ordered the National Security Council to the Situation Room
Netanyahu Signals Potential Regime Change in Iran
Analysts Warn Iran May Resort to Unconventional Warfare
Iranian Regime Faces Existential Threat Amid Conflict
Energy Infrastructure Becomes War Zone in Middle East
Iran Conducts Ballistic Missile Launches Amid Heightened Tensions with Israel
Iran Signals Openness to Nuclear Negotiations Amid Ongoing Regional Tensions
Shock Within Iran’s Leadership: Khamenei’s Failed Plan to Launch 1,000 Missiles Against Israel
Trump's Anti-War Stance Tested Amid Israel-Iran Conflict
UK Deploys Jets to Middle East Amid Rising Tensions
Exiled Iranian Prince Reza Pahlavi Urges Overthrow of Khamenei Regime
Wreck of $17 Billion San José Galleon Identified Off Colombia After 300 Years
Iran Launches Extensive Missile Attack on Israel Following Israeli Strikes on Nuclear Sites
Israel Issues Ultimatum to Iran Over Potential Retaliation and Nuclear Facilities
Black Box Recovered from Air India Crash Site
Coinbase CEO Warns Bitcoin Could Supplant US Dollar Amid Mounting National Debt
Trump to Iran: Make a Deal — Sign or Die
Operation "Like a Lion": Israel Strikes Iran in Unprecedented Offensive
Israel Launches 'Operation Rising Lion' Targeting Iranian Nuclear and Military Sites
Israeli Forces Intercept Gaza-Bound Aid Vessel Carrying Greta Thunberg
IMF Warns of Severe Global Trade War Impacts on Emerging Markets
Syria to Reconnect to Global Economy After 14 Years of Isolation
Israel Confirms Arming Gaza Clan to Counter Hamas Influence
Global News Roundup: From Ukraine's strategic military strikes and Russia's demands and Tensions Escalate in Ukraine, to serious legal issues faced by Britons in Bali and Trump's media criticism, the latest developments highlight a turbulent landscape
U.S. Reduces Military Presence in Syria
Trump Demands Iran End All Uranium Enrichment in Nuclear Talks
Iran Warns Europe Against Politicizing UN Nuclear Report
Paris Saint-Germain's Greatest Triumph Is Football’s Lowest Point
OPEC+ Agrees to Increase Oil Output for Third Consecutive Month
Turkey Detains Istanbul Officials Amid Anti-Corruption Crackdown
Meta and Anduril Collaborate on AI-Driven Military Augmented Reality Systems
EU Central Bank Pushes to Replace US Dollar with Euro as World’s Main Currency
European and Arab Ministers Convene in Madrid to Address Gaza Conflict
U.S. Health Secretary Ends Select COVID-19 Vaccine Recommendations
Trump Warns Putin Is 'Playing with Fire' Amid Escalating Ukraine Conflict
India and Pakistan Engage Trump-Linked Lobbyists to Influence U.S. Policy
U.S. Halts New Student Visa Interviews Amid Enhanced Security Measures
Trump Administration Cancels $100 Million in Federal Contracts with Harvard
SpaceX Starship Test Flight Ends in Failure, Mars Mission Timeline Uncertain
King Charles Affirms Canadian Sovereignty Amid U.S. Statehood Pressure
×